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Related Experiment Videos

Circulating digitalis-like factors.

V M Buckalew1

  • 1Department of Medicine, Bowman Gray School of Medicine, Winston Salem, NC 27103.

Pediatric Nephrology (Berlin, Germany)
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

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Mammalian plasma and tissues contain endogenous compounds that regulate Na, K ATPase, mimicking digitalis glycosides. These factors, including lipids and steroids, may modulate cardiovascular function.

Area of Science:

  • Biochemistry
  • Physiology
  • Cardiovascular Research

Background:

  • Mammalian plasma and tissue extracts exhibit biologic activities similar to digitalis glycosides.
  • This suggests the presence of endogenous regulators for the Na, K ATPase enzyme.

Purpose of the Study:

  • To identify and characterize endogenous compounds with digitalis-like activity.
  • To investigate the role of these compounds in cardiovascular regulation.

Main Methods:

  • Purification of plasma extracts to isolate active compounds.
  • Analysis of tissue, particularly the hypothalamus, for digitalis-like factors.
  • Characterization of identified lipids and steroids.

Main Results:

Related Experiment Videos

  • Several classes of circulating lipids (fatty acids, lysophospholipids, arachidonic acid metabolites) show digitalis-like activity.
  • Circulating steroids like dehydroepiandrosterone sulfate and hydrocortisone also possess this activity.
  • A unique, low molecular weight digitalis-like factor (DLF) was identified in the hypothalamus and circulates in plasma.

    • Conclusions:

    • Endogenous digitalis-like factors, including lipids, steroids, and a hypothalamic factor, regulate Na, K ATPase.
    • These factors may act as modulators of cardiovascular function by influencing renal sodium excretion and peripheral vascular resistance.