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Related Concept Videos

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury04:19

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Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and...
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Source: Macheda, T., et. al. Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice. J. Vis. Exp. (2022)This video demonstrates the procedure to induce a closed-head injury in a mouse model using a stereotaxic frame. The controlled impact replicates mild traumatic brain injury, allowing researchers to study neurological effects and recovery by measuring post-injury reflexes and...
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Related Experiment Video

Updated: Jan 19, 2026

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Multiple Mild Traumatic Brain Injuries Lead to Visual Dysfunction in a Mouse Model.

Abhishek Desai1, Huazhen Chen1,2, Hee-Yong Kim1

  • 1Laboratory of Molecular Signaling, NIAAA, NIH, Rockville, Maryland.

Journal of Neurotrauma
|September 19, 2019
PubMed
Summary
This summary is machine-generated.

Repeated mild traumatic brain injury (TBI) in mice significantly impairs visual function and performance on cognitive tasks. These visual deficits, linked to optic tract changes, may serve as markers for monitoring TBI outcomes.

Keywords:
CHIMERAVEPbehaviorrepeated TBIvisual acuity

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Related Experiment Videos

Last Updated: Jan 19, 2026

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Trauma Research

Background:

  • Visual dysfunction is a frequent consequence of traumatic brain injury (TBI).
  • Understanding the impact of single versus multiple mild TBIs on visual function is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the effects of single or multiple mild TBIs on visual function in a mouse model.
  • To assess behavioral and physiological changes associated with repeated mild TBI.

Main Methods:

  • Utilized the closed head injury by mechanically engineered rotational acceleration (CHIMERA) device to induce single or triple mild TBIs in mice.
  • Evaluated visual function through Morris water maze, visual cliff, and open field tests.
  • Measured visual evoked potential (VEP) and analyzed optic tract glial cell immunostaining (GFAP, Iba1) post-injury.

Main Results:

  • Multiple TBIs led to impaired performance in the visible platform water maze and increased errors in the visual cliff test.
  • A graded reduction in VEP N1 amplitude was observed, with multiple TBIs causing a significant decrease compared to sham and single TBI groups.
  • Increased GFAP immunostaining was noted in both single and multiple TBI groups, while Iba1 staining significantly increased only in the multiple TBI group's optic tract.

Conclusions:

  • Repeated mild TBI using the CHIMERA model results in significant visual deficits and affects behavioral performance.
  • Changes in visual function and optic tract glial response may serve as valuable biomarkers for monitoring TBI progression and screening neuroprotective agents.