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Related Experiment Video

Updated: Jan 19, 2026

Generation of Chikungunya Virus-Like Particles Using Baculovirus Expression System in Insect Cells
03:05

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Chikungunya arthritis.

Himanshu Pathak1, Mithun C Mohan2, Vinod Ravindran3

  • 1Tricolour Hospitals, Vadodara, India.

Clinical Medicine (London, England)
|September 19, 2019
PubMed
Summary
This summary is machine-generated.

Chikungunya virus (CHIKV) infection causes widespread joint pain and is a growing global health issue. Recent advances improve understanding and management of CHIKV arthritis, aiding new treatments and prevention.

Keywords:
Chikungunya infectionDMARDschronic arthritischronic inflammatory rheumatismmethotrexateviral arthritis

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Area of Science:

  • Virology
  • Epidemiology
  • Immunology

Background:

  • Chikungunya virus (CHIKV) infection has become a significant global public health concern, particularly in Asia and South America, with increasing cases in North America and Europe due to travel.
  • CHIKV infection primarily manifests as musculoskeletal symptoms, including chronic polyarthritis that can mimic autoimmune inflammatory arthritis.
  • The virus should be suspected in travelers presenting with fever, rash, and joint pain.

Purpose of the Study:

  • To review recent advancements in the epidemiology of CHIKV infection.
  • To discuss the immunopathogenesis of chikungunya infection.
  • To explore current and emerging management strategies for CHIKV arthritis.

Main Methods:

  • This narrative review synthesizes current literature on CHIKV.
  • Focuses on epidemiological trends, disease mechanisms, and clinical management.
  • Highlights recent research and clinical observations.

Main Results:

  • Epidemics since 2004 have significantly expanded knowledge of CHIKV.
  • Understanding of CHIKV immunopathogenesis has notably increased.
  • This enhanced knowledge is driving the development of novel therapeutic and preventive approaches.

Conclusions:

  • CHIKV arthritis presents a diagnostic challenge, often resembling autoimmune conditions.
  • Continued research into CHIKV epidemiology and immunopathogenesis is crucial.
  • Advances are paving the way for improved treatment and control of chikungunya infections and their sequelae.