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Updated: Jan 19, 2026

Fiber Optic Distributed Sensors for High-resolution Temperature Field Mapping
Published on: November 7, 2016
Detection of dengue using PAMAM dendrimer integrated tapered optical fiber sensor
Yasmin Mustapha Kamil1, Sura H Al-Rekabi2, Mohd Hanif Yaacob1
1Wireless and Photonic Networks Research Centre, Faculty of Engineering, Universiti Putra Malaysia, 43400, Serdang, Malaysia.
Abstract:
The exponential escalation of dengue cases has indeed become a global health crisis. This work elaborates on the development of a biofunctionalized tapered optical fiber (TOF) based sensor with the integration of polyamidoamine (PAMAM) dendrimer for the detection of dengue E protein. The dimension of the TOF generated an evanescent field that was sensitive to any changes in the external medium while the integration of PAMAM promoted more adhesion of bio-recognition molecules; anti-DENV II E protein antibodies; that were complementary to the targeted protein. This in return created more active sites for the absorption of DENV II E proteins onto the tapered region. The resolution and detection limit of the sensor are 19.53 nm/nM and 1 pM, respectively with Kd = 1.02 × 10-10 M.
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