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Related Experiment Video

Updated: May 21, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
09:09

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions

Published on: November 23, 2015

Non-enzymatic dual-mode plasmonic framework for robust bioanalyte detection.

Olabisi Abdullahi Onifade1, Mundzir Abdullah2, Muhammad Hafiz Abu Bakar3

  • 1Institute of Nano Optoelectronics Research and Technology (INOR), Universiti Sains Malaysia, 11800, Penang, Malaysia.

Scientific Reports
|May 19, 2026
PubMed
Summary

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This summary is machine-generated.

This study introduces a novel dual-mode plasmonic sensor for accurate uric acid (UA) detection in complex samples. The non-enzymatic sensor offers high sensitivity and stability for point-of-care diagnostics.

Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Accurate point-of-care quantitation of biological analytes like uric acid (UA) is challenging due to complex media and sensor instability.
  • Conventional sensors face interference and limited stability, hindering reliable real-time monitoring of clinically significant bioanalytes.

Purpose of the Study:

  • To develop a non-enzymatic, dual-mode plasmonic sensing strategy for enhanced uric acid detection.
  • To create a robust, regenerable, and interference-resistant platform for point-of-care bioanalysis.

Main Methods:

  • Integration of propagating surface plasmons and localized nanoparticle-driven resonances in a multilayer nanostructure (gold film, APTES-modified gold nanoparticles, reduced graphene oxide).
  • Utilized a dual-mode plasmonic approach to enhance light-matter interaction and optical signal definition for sensing.
Keywords:
BioanalyteDual-modeGold nanoparticlesPlasmonicsReduced graphene oxide

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Last Updated: May 21, 2026

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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Published on: November 23, 2015

Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
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Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis

Published on: March 7, 2018

  • Evaluated sensor performance including sensitivity, detection limit, binding affinity, selectivity, and long-term stability.

    • Main Results:

    • Achieved high sensitivity (0.2258°/(mg/dL)) and a low detection limit (0.0446 mg/dL) for uric acid.
    • Demonstrated significant interference suppression (~10%) and high binding affinity (1451.85 (mg/dL)⁻¹).
    • Exhibited excellent long-term stability (90% over 90 days) and regenerability (97.2% sensitivity retention over 10 cycles).

    Conclusions:

    • The developed dual-mode plasmonic sensor offers a robust and reliable platform for real-time uric acid monitoring.
    • The strategy shows promise for adaptation to other clinically relevant bioanalytes, advancing point-of-care diagnostics.