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Updated: Jan 19, 2026

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(ii) complex inducing apoptosis in
Junshuai Zhang1, Jiyong Hu1, Kun Peng2
1College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China.
Abstract:
A novel hexanuclear copper(ii)-based complex, [Cu6(tpbb)2(NO3)12] (1), was synthesized, which shows potent cytotoxicity to hepatoma carcinoma cells by inducing apoptosis and apoptosis-related processes. Furthermore, mechanistic investigations based on proteomes revealed that the induced apoptosis was mediated by acting on several targets and multiple pathways in a pleiotropic way.
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