Related Experiment Video
Updated: Jan 19, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Creating Diversity from Biomass: A Tandem Bio/Metal-Catalysis towards Chemoselective Synthesis of Densely Substituted
João M J M Ravasco1, Carlos M Monteiro1, Filipa Siopa1
1Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal.
Abstract:
A new chemoselective (enzymatic desymmetrization/Ru-catalyzed C-H activation) sequence to obtain differently substituted furans from the largely available 2,5-furandicarboxylic acid (FDCA) was developed. Series of di- and trisubstituted furans were prepared in very good yields and excellent chemoselectivity. This study discloses a new approach towards valorization of the furanics platform through the use of FDCA as a stable intermediate, thus circumventing the chemical instability of the parent 5-hydroxymethylfurfural.
Related Concept Videos
02:50Catalysis
07:06A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
08:23Introduction to Catalysis
Catalysis is among the most important fields of modern technology and presently accounts for approximately 35% of the gross domestic product (GDP) and sustenance of approximately 33% of the global population through fertilizers produced via the Haber process.1 Catalysts are systems that facilitate chemical reactions by lowering the activation energy and influencing the selectivity. Catalysis will be a central technology in...
02:52Synthesis of Metal Oxide Microcapsules Using Metal-Reducing Bacteria
07:30Fast Pyrolysis of Biomass Residues in a Twin-screw Mixing Reactor
11:05Quadruply Metal-Metal Bonded Paddlewheels
Paddlewheel complexes are a class of compounds comprised of two metal ions (1st, 2nd, or 3rd row transition metals) held in proximity by four bridging ligands (most commonly formamidinates or carboxylates) (Figure 1). Varying the identity of the metal ion and the bridging ligand provides access to large families of paddlewheel complexes. The structure of paddlewheel complexes allows for metal-metal bonding,...