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Updated: Jan 15, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis and meta-Amination of Pyridines via Multicomponent Cascade Reaction
Telmo N Francisco1, Nuno R Candeias1,2, Samuel Guieu1
1LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Abstract:
We report a green, multicomponent cascade synthesis of 3-aminopyridines via [1,3'-bipyridin]-1-ium intermediates undergoing Zincke aminolysis with ammonia supported by experimental evidence and DFT calculations. The method offers broad scope (>20 examples), good functional group tolerance, and scalability in batch and flow procedures. Synthetic utility is demonstrated through conversion into 3-halo, 3-hydroxy, and 3-thiopyridines, expanding the access to meta-substituted pyridines through peripheral editing of the unprotected amino group.
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