Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine-mediated circling behaviour does not involve the nigro-tectal pathway.

C Reavill, N Leigh, P Jenner

    Experimental Brain Research
    |October 1, 1979
    PubMed
    Summary

    Superior colliculus lesions did not affect circling behavior in rats with nigro-striatal pathway damage. A dorsal tegmental decussation lesion partially reduced circling, suggesting a minor role for interhemispheric pathways.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effect of withdrawal of dopaminergic medication on simple and choice reaction time and the use of advance information in Parkinson's disease.

    Journal of neurology, neurosurgery, and psychiatry·1992
    Same author

    New insights into the cause of Parkinson's disease.

    Neurology·1992
    Same author

    Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group.

    Annals of neurology·1992
    Same author

    Fronto-striatal cognitive deficits at different stages of Parkinson's disease.

    Brain : a journal of neurology·1992
    Same author

    Corticobasal degeneration.

    Bailliere's clinical neurology·1992
    Same author

    "Isolated" postinfectious myoclonus.

    Journal of neurology, neurosurgery, and psychiatry·1992

    Area of Science:

    • Neuroscience
    • Neuropharmacology
    • Dopaminergic pathways

    Background:

    • Unilateral 6-hydroxydopamine lesions create a model for studying dopamine-related motor asymmetry.
    • The superior colliculus and nigro-striatal pathway are key components of motor control.
    • The role of nigro-tectal pathways in mediating circling behavior is not fully understood.

    Purpose of the Study:

    • To investigate the role of the superior colliculus in mediating drug-induced rotation.
    • To determine if nigro-tectal pathways are essential for circling behavior.
    • To explore the involvement of interhemispheric connections in circling responses.

    Main Methods:

    • Electrolytic ablation of the rat superior colliculus (unilateral or bilateral).
    • Unilateral 6-hydroxydopamine lesions of the nigro-striatal dopaminergic pathway.

    Related Experiment Videos

  • Administration of apomorphine and amphetamine to induce rotation.
  • Electrolytic lesions of the dorsal tegmental decussation.

    • Main Results:

    • Superior colliculus ablation did not alter apomorphine- or amphetamine-induced rotation.
    • Lesions of the dorsal tegmental decussation reduced apomorphine-induced rotation but not amphetamine-induced rotation.
    • Findings suggest the nigro-tectal pathway is not critical for dopamine-induced circling.

    Conclusions:

    • The nigro-tectal pathway does not play a significant role in mediating circling behavior from striatal dopamine receptor stimulation.
    • Interhemispheric pathways, potentially sectioned by dorsal tegmental decussation lesions, may play a limited role in circling responses.