Design and characterization of an organogel system containing ascorbic acid microparticles produced with propolis...

This study aimed to prepare and characterize organogels containing microparticles of ascorbic acid (AA) obtained from propolis by-product. The formulations F1 (5% of microparticles) and F2 (10% of microparticles) were evaluated regarding rheological and textural properties, antioxidant and radical scavenging activity, in vitro release and cellular studies. The organogels showed plastic flow behavior and rheopexy. The textural parameters were within acceptable values for semisolid formulations. The antioxidant capacity of organogels F1 and F2 by the DPPH assay demonstrated IC₅₀ ranging from 1523.59 to 1166.97 μg/mL, respectively. For the FRAP assay, the values found were 842.88 and 956.14 μmol of FSE/g formulation, respectively. Good scavenging activity against nitrogen species was observed. The concentration of 63 μg/mL did not present toxicity on HaCaT and HFF-1 cells. In vitro release profile of AA from organogels showed a slow pattern of drug release, mainly for F2. Therefore, the proposed organogel containing AA microparticles with propolis by-product matrix represents a promising platform for topical drug delivery with antioxidant effect.