[The antimicrobial strategies of neutrophils under infection pathology.]

The neutrophilic granulocytes were traditionally considered exclusively as phagocytes - killer cells of microorganisms invaded human organism. The discoveries of last decade permitted to significantly reconsider this role and importance of neutrophils in implementation of affect mechanisms of inherent and adaptive immunity. The modern achievements expanded our conceptions about anti-microbial strategies of neutrophilic granulocytes under infection pathology: phagocytosis, degranulation and development of neutrophil extracellular traps. These strategies also play a key role in damage of tissues, providing cytotoxic functions. The article presents actual data concerning the role of interaction between neutrophils and adaptive immune cells in development of mechanism of destructive pathological activation of immune response that results in an auto-aggression, induction of chronic inflammation and development of oncologic and auto-immune diseases.