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Updated: Jan 19, 2026

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Re-visiting post-breast surgery pain syndrome: risk factors, peripheral nerve associations and clinical implications
George Kokosis1, Karan Chopra1, Halley Darrach1
1Department of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD, USA.
Abstract:
Aesthetic and reconstructive breast surgery is among the most common operations performed by plastic surgeons. The prevalence of persistent pain after breast surgery remains underappreciated by plastic surgeons. Post breast surgery pain syndrome (PBSPS) is reported to range between 20-60%. It is the purpose of this paper to revisit chronic pain as a combination of the breast intervention and relate this to the peripheral nerve(s) transmitting the pain message, in order to understand the underlying etiology and to improve breast pain treatment outcomes.
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