Related Experiment Video
Updated: Jan 19, 2026

Dissecting Mechanoenzymatic Properties of Processive Myosins with Ultrafast Force-Clamp Spectroscopy
Published on: July 1, 2021
Beating to rotational transition of a clamped active ribbon-like filament
Shalabh K Anand1, Raghunath Chelakkot, Sunil P Singh
1Department of Physics, Indian Institute of Science Education and Research, Bhopal 462 066, Madhya Pradesh, India. skanand@iiserb.ac.in spsingh@iiserb.ac.in.
Abstract:
We present a detailed study of a clamped ribbon-like filament under a compressive active force using Brownian dynamics simulations. We show that a clamped ribbon-like filament is able to capture beating as well as rotational motion under the compressive force. The nature of oscillation is governed by the torsional rigidity of the filament. The frequency of oscillation is almost independent of the torsional rigidity. The beating of the filament gives a butterfly-shaped trajectory of the free-end monomer, whereas rotational motion yields a circular trajectory on a plane. The binormal correlation and the principal component analysis reveal the butterfly, elliptical, and circular trajectories of the free end monomer. We present a phase diagram for different kinds of motion in the parameter regime of compressive force and torsional rigidity.
Related Concept Videos
Generation of Straight or Branched Actin Filaments
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
Actin Filament Depolymerization
In F-actin, the ADF/cofilin proteins...
Mechanism of Filopodia Formation
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Formation of Higher-order Actin Filaments
The high-order actin...
Assembly of Cytoskeletal Filaments
Adaptability of Cytoskeletal Filaments

