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Updated: Jan 19, 2026

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
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Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

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Post-translational modification of SOX family proteins: Key biochemical targets in cancer?

Charles A C Williams1, Abdenour Soufi1, Steven M Pollard1

  • 1MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, EH16 4UU, Edinburgh, United Kingdom.

Seminars in Cancer Biology
|September 21, 2019
PubMed

Insights

Sox proteins control cell identity and are implicated in cancer. Post-translational modifications (PTMs) regulate Sox proteins, offering potential therapeutic targets for cancer drug discovery.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cancer Biology

Background:

  • Sox proteins are transcription factors crucial for stem cell self-renewal and multipotency.
  • Their overexpression is linked to various human cancers, making them significant therapeutic targets.
  • Targeting Sox proteins directly with structure-based drugs is challenging.

Purpose of the Study:

  • To review the post-translational modifications (PTMs) of Sox proteins.
  • To explore the functional importance of these PTMs in cell fate determination.
  • To identify potential drug targets for cancer therapy.

Main Methods:

  • Literature review of reported post-translational modifications of Sox proteins.
  • Analysis of the functional roles of PTMs in stem cell biology and cancer.
  • Identification of enzymes regulating Sox protein PTMs.

Main Results:

  • Sox protein localization, activity, and interactions are modulated by diverse PTMs, including phosphorylation, acetylation, sumoylation, methylation, and ubiquitylation.
  • These modifications play a critical role in guiding cell fate processes.
  • Enzymes regulating Sox PTMs represent promising targets for anti-cancer drug development.

Conclusions:

  • Post-translational modifications are key regulators of Sox protein function.
  • Understanding Sox protein PTMs provides new avenues for therapeutic intervention in cancer.
  • Enzymes involved in Sox PTMs are potential targets for novel anti-cancer drugs.
Keywords:
CancerPost-translational modificationSOXStem cellTranscription

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