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Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case
Arina Yamasaki1, Daisuke Bito2, Erina Eto2
1Diabetes and Endocrinology, Saga-Ken Medical Centre Koseikan, 400 Nakabaru, Kase-machi, Saga-shi, Saga, 840-8571, Japan. arena07211084@gmail.com.
Background:
Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial features, body types, and metabolic abnormalities due to the excessive secretion of growth hormone by a pituitary adenoma. Growth hormone has been reported to be involved in glomerular cell growth, mesangial proliferation, and glomerulosclerosis in the kidney.
Case Presentation:
We report a case of a Japanese patient with focal segmental glomerulosclerosis in whom decreased urinary protein was observed after surgical treatment for acromegaly.
Conclusion:
The patient's urinary protein improved as the concentration of growth hormone/insulin-like growth factor 1 decreased.
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