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RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6
Summary
Methyl 2-octynoate demonstrates no genotoxicity and is not expected to be phototoxic. Safety assessments indicate acceptable risk levels for skin sensitization, repeated dose, and developmental toxicity, with environmental safety confirmed.
Area of Science:
- Chemical safety assessment
- Toxicology
- Environmental risk evaluation
Background:
- Methyl 2-octynoate is a chemical compound requiring comprehensive safety evaluation.
- Understanding its toxicological profile is crucial for regulatory compliance and safe handling.
- Environmental impact assessment is necessary for sustainable use.
Purpose of the Study:
- To evaluate the genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety of methyl 2-octynoate.
- To determine the safety margins and potential risks associated with methyl 2-octynoate exposure.
- To ensure compliance with regulatory standards for chemical safety and environmental protection.
Main Methods:
- Genotoxicity assays were performed.
- Skin sensitization was assessed to determine the No Expected Significant Increase Level (NESIL).
- Toxicity endpoints (repeated dose, developmental and reproductive, local respiratory) were evaluated using the Threshold of Toxicological Concern (TTC) for Cramer Class II materials.
- Phototoxicity/photoallergenicity was evaluated using UV spectra.
- Environmental safety was assessed based on PBT criteria and risk quotients (PEC/PNEC).
Main Results:
- Methyl 2-octynoate was found to be non-genotoxic.
- A NESIL of 110 μg/cm² was established for skin sensitization.
- Exposure levels for repeated dose, developmental and reproductive, and local respiratory toxicity were below the TTC.
- Methyl 2-octynoate is not expected to be phototoxic or photoallergenic.
- The compound was found not to be Persistent, Bioaccumulative, and Toxic (PBT) and exhibited risk quotients <1 for environmental safety.
Conclusions:
- Methyl 2-octynoate presents a favorable safety profile regarding genotoxicity and phototoxicity.
- The established safety margins indicate low risk for skin sensitization, systemic toxicity, and local respiratory effects.
- Environmental risk assessment confirms methyl 2-octynoate is not PBT and poses minimal environmental risk at current usage volumes.
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