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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Inflammation01:38

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Inflammatory Response I: Vascular and Cellular01:30

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Appendicitis-I: Introduction01:22

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
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TLI in pediatric patients.

A Ocanto1, A Escribano2, L Glaría2

  • 1Radiation Oncology Department, Hospital Universitario La Paz, Pº de La Castellana, 261, Madrid, 28046, Spain. abraham.ocanto@gmail.com.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|September 23, 2019
PubMed
Summary
This summary is machine-generated.

Total lymphoid irradiation (TLI) conditioning for haploidentical hematopoietic stem cell transplantation (HSCT) offers a feasible alternative to total body irradiation (TBI). This reduced-intensity conditioning shows promise for patients lacking HLA-matched donors, with minimal toxicity and high survival rates.

Keywords:
HaploidenticPediatricsTLITotal lymphoid irradiation oncology

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Area of Science:

  • Hematology
  • Radiation Oncology
  • Immunology

Background:

  • Hematopoietic progenitor cell transplantation (HSCT) is a curative treatment for various hematological diseases.
  • Finding HLA-compatible donors for haploidentical transplantation can be challenging for some patients.
  • Traditional total body irradiation (TBI) conditioning has limitations.

Purpose of the Study:

  • To evaluate reduced-intensity conditioning using total lymphoid irradiation (TLI) as an alternative to TBI for haploidentical HSCT.
  • To assess TLI's efficacy in patients lacking HLA-compatible donors.

Main Methods:

  • A cohort of 25 patients with hematological diseases underwent haploidentical HSCT.
  • Conditioning involved TLI (8 Gy total dose) using IMRT and VMAT techniques, followed by thiotepa and melphalan.
  • Prophylaxis included ciclosporin; transplantation occurred from February 2015 to May 2018.

Main Results:

  • Transplant rejection rate was 12%.
  • Acute graft-versus-host disease (GVHD) grade < II occurred in 48% of patients, with chronic GVHD at 12%.
  • No acute toxicity was observed in irradiated patients, and the overall survival rate was 56%.

Conclusions:

  • Conditioning haploidentical transplants with TLI, IMRT, and VMAT is a feasible technique.
  • This method effectively induces immunosuppression, reduces graft rejection risk, and minimizes adverse effects.
  • The TLI-based approach demonstrates a low incidence of GVHD and a high survival rate compared to TBI.