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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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The effect of idiopathic premature ventricular complexes on left ventricular ejection fraction

Bernas Altıntaş1, Flora Özkalaycı2, Göksel Çinier3

  • 1Department of Cardiology, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|September 23, 2019
PubMed

Insights

This study found that a higher burden of premature ventricular complexes (PVCs), along with age and QRS duration, is linked to a decrease in left ventricular ejection fraction (LVEF). This inverse relationship was observed at lower PVC burdens than previously recognized.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiovascular Imaging

Background:

  • Idiopathic premature ventricular complexes (PVCs) are common arrhythmias.
  • A definitive threshold for PVC burden predicting cardiomyopathy (CMP) is lacking in current literature.
  • Understanding the relationship between PVC burden and left ventricular function is crucial.

Purpose of the Study:

  • To evaluate the relationship between PVC burden and left ventricular ejection fraction (LVEF).
  • To identify predictors of decreased LVEF in patients with idiopathic PVCs.

Main Methods:

  • A multicenter, cross-sectional study involving 341 patients with >1,000 idiopathic PVCs per 24 hours.
  • Primary outcome: LVEF measured via echocardiography.
  • Statistical analysis using proportional odds logistic regression.

Main Results:

  • Increased PVC burden (%), PVC QRS duration, and age were associated with decreased LVEF.
  • An inverse relationship between PVC burden and LVEF was evident, particularly when PVC burden exceeded 5%.
  • A nomogram was developed to estimate individual risk for LVEF decrease.

Conclusions:

  • Higher PVC burden, age, and PVC QRS duration are independent predictors of reduced LVEF in idiopathic PVC patients.
  • The study identified a lower PVC burden threshold associated with decreased LVEF than previously established.
  • These findings aid in risk stratification and management of patients with idiopathic PVCs.
Abstract

Keywords:
cardiomyopathyleft ventricular ejection fractionpremature ventricular complexes

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