Engineering inkjet bioprinting processes toward translational therapies

Area of Science:

• Biomedical Engineering
• Materials Science
• Regenerative Medicine

Background:

• 3D bioprinting constructs tissues using cell-laden biomaterials via additive manufacturing.
• Inkjet printing offers high resolution for bioprinting, crucial for tissue engineering.
• Clinical translation of bioprinting faces significant process engineering challenges.

Purpose of the Study:

• To review recent advances in inkjet-based 3D bioprinting.
• To emphasize available biomaterials, their properties, and construct generation for medical applications.
• To address current challenges and future directions for bioprinting and bioinks, focusing on mass production and regulatory aspects.

Main Methods:

• Review of recent advancements in inkjet-based 3D bioprinting technologies.
• Analysis of biomaterials used in bioprinting, including their properties and synthesis.
• Examination of upstream (bioink formulation) and downstream (sterilization, culture, implantation) challenges.

Main Results:

• Recent progress in bioink development and inkjet bioprinting techniques.
• Identification of key biomaterials and their suitability for specific medical applications.
• Highlighting the critical need for scalable manufacturing and regulatory compliance.

Conclusions:

• Bioprinting holds immense potential for tissue engineering and regenerative medicine.
• Addressing challenges in bioink formulation, process engineering, and regulatory pathways is essential for clinical impact.
• Future efforts must focus on mass production and adherence to regulatory standards for successful translation.