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Near-Infrared Optogenetic Genome Engineering Based on Photon-Upconversion Hydrogels.

Yoichi Sasaki1, Mio Oshikawa2, Pankaj Bharmoria1

  • 1Department of Chemistry and Biochemistry, Graduate School of Engineering, Center for Molecular Systems (CMS), Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.

Angewandte Chemie (International Ed. in English)
|September 24, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed new organic hydrogels for near-infrared (NIR) optogenetics, enabling deep tissue manipulation. This biocompatible material overcomes limitations of inorganic nanoparticles for advanced optogenetic applications.

Keywords:
genome engineeringnear-infrared lightphoton upconversionsinglet-to-triplet absorptiontriplet-triplet annihilation

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Area of Science:

  • Biomaterials Science
  • Optogenetics
  • Nanotechnology

Background:

  • Near-infrared (NIR) light enables optogenetics in deep tissues, but materials are limited to inorganic nanoparticles.
  • Organic materials offer potential for biocompatible NIR optogenetics.

Purpose of the Study:

  • To develop biocompatible, organic hydrogels for NIR-light-triggered optogenetics.
  • To overcome challenges in triplet sensitization within viscous hydrogel matrices.

Main Methods:

  • Covalently linking NIR-absorbing complexes with energy-pooling acceptors to prolong donor triplet lifetime.
  • Solubilizing components in Pluronic F127 hydrogels and applying heat treatment for oxygen tolerance.
  • Integrating with photoactivatable Cre recombinase technology for genome engineering.

Main Results:

  • Demonstrated successful NIR-light-triggered optogenetics using organic TTA-UC hydrogels.
  • Achieved enhanced triplet sensitization and oxygen tolerance in hydrogel matrices.
  • Successfully performed genome engineering in hippocampal neurons, forming dendritic-spine-like structures.

Conclusions:

  • Biocompatible organic TTA-UC hydrogels represent a novel material for NIR optogenetics.
  • This approach expands the toolkit for deep-tissue optogenetic manipulation and genome engineering.