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Laser-assisted biomineralization on human dentin for tooth surface functionalization.

Ayako Oyane1, Noriyuki Saito2, Ikuko Sakamaki1

  • 1Nanomaterials Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.

Materials Science & Engineering. C, Materials for Biological Applications
|September 25, 2019
PubMed
Summary

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A novel laser-assisted biomimetic (LAB) process rapidly mineralized human dentin surfaces. This technique created a hydroxyapatite layer, offering a new method for tooth surface modification and functionalization.

Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Nanotechnology

Background:

  • Biocompatible calcium phosphate (CaP) coatings show promise for dental applications.
  • Existing methods for CaP coating on artificial materials are limited.
  • A laser-assisted biomimetic (LAB) process offers facile and area-specific CaP coating.

Purpose of the Study:

  • To investigate the rapid biomineralization of human dentin using the LAB process.
  • To evaluate the effectiveness of LAB in creating a mineralized layer on dentin.
  • To explore the potential of LAB for tooth surface modification.

Main Methods:

  • Human dentin substrates were immersed in a supersaturated CaP solution.
  • The dentin surface was irradiated with weak pulsed laser light for 30 minutes (LAB process).
Keywords:
Biomimetic processCalcium phosphate (CaP)CoatingDentinHydroxyapatiteLaser

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  • Ultrastructural analyses were performed to examine the surface changes.

    • Main Results:

    • The LAB process removed the demineralized collagenous layer on the dentin surface.
    • A submicron-thick hydroxyapatite layer formed on the dentin substrate.
    • The mineralized layer consisted of needle-like hydroxyapatite nanocrystals with oriented c-axes.

    Conclusions:

    • The LAB process induces pseudo-biomineralization on human dentin.
    • Laser irradiation facilitates CaP nucleation and growth on the dentin surface.
    • The LAB process provides a novel tool for in situ tooth surface modification and functionalization.