Hydroxyapatite Block Produced by Sponge Replica Method: Mechanical, Clinical and Histologic Observations.
Antonio Scarano1,2, Felice Lorusso3, Pablo Santos de Oliveira4
1Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy. ascarano@unich.it.
Materials (Basel, Switzerland)
|September 25, 2019
Summary
Hydroxyapatite (HA) porous scaffolds effectively treated maxillary bone defects in humans. This study showed significant new bone formation, supporting HA scaffolds for dental implant procedures.
Area of Science:
- Biomaterials Science
- Oral and Maxillofacial Surgery
- Regenerative Medicine
Background:
- Grafting procedures augment jaw bone volume for dental implants.
- Maxillary bone defects pose challenges for oral rehabilitation.
- Hydroxyapatite (HA) scaffolds offer potential for bone regeneration.
Purpose of the Study:
- Evaluate a hydroxyapatite (HA) porous scaffold for treating maxillary bone defects.
- Assess the efficacy of HA scaffolds in a human model for oral rehabilitation.
- Investigate the osteoconductive properties of HA scaffolds in sinus lifting procedures.
Main Methods:
- 13 patients underwent sinus lifting in the posterior maxilla, treating 16 defects with cylindrical HA blocks.
- 3D Cone Beam Computer Tomography (CBCT) scans evaluated experimental sites.
- Histological analysis was performed after a 3-month healing period.
Main Results:
- Histological analysis revealed high osteoconduction of HA scaffolds.
- New bone formation was observed within the HA graft blocks.
- Graft composition included 39% new bone, 42% marrow space, 17% residual HA, and 4% osteoid.
Conclusions:
- Porous HA scaffolds produced via sponge replica are effective for human maxillary bone defects.
- The study supports the use of HA scaffolds in regenerative dentistry.
- HA scaffolds demonstrate significant potential for bone augmentation in oral surgery.
