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Graphene-Based Sensing Platform for On-Chip Ochratoxin A Detection.

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We developed a graphene field-effect transistor (GFET) aptasensor for rapid ochratoxin A (OTA) detection. This cost-effective sensor offers fast response and high sensitivity for toxin analysis in real samples.

Keywords:
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Area of Science:

  • Nanotechnology
  • Biosensors
  • Analytical Chemistry

Background:

  • Ochratoxin A (OTA) is a common food contaminant with significant health risks.
  • Existing methods for OTA detection can be time-consuming and expensive.
  • There is a need for rapid, sensitive, and cost-effective on-chip detection platforms.

Purpose of the Study:

  • To develop and characterize an on-chip aptasensor for ochratoxin A (OTA) detection.
  • To utilize graphene field-effect transistor (GFET) technology for enhanced sensor performance.
  • To demonstrate the sensor's applicability in real-world samples.

Main Methods:

  • Fabrication of graphene-based field-effect transistor (GFET) devices using large-scale technology.
  • Covalent bonding of aptamers specific to OTA onto the graphene surface.
  • Testing sensor response, detection limits, regeneration time, reproducibility, and selectivity.

Main Results:

  • The aptasensor demonstrated a fast response time (within 5 minutes) to OTA.
  • Achieved a wide linear detection range (10 pg/mL to 4 ng/mL) with a low detection limit (4 pg/mL).
  • Showed high reproducibility, fast sensor regeneration (5.6 s), and successful application to spiked red wine samples with ~105% recovery.

Conclusions:

  • The developed GFET aptasensor provides a sensitive, rapid, and reproducible method for OTA detection.
  • The large-scale fabrication capability ensures cost-effectiveness and potential for upscaling.
  • This platform holds promise for multiplexed on-chip toxin sensing applications.