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Urinary bisphenol A and serum lipids: a meta-analysis of six NHANES examination cycles (2003-2014)
Linda Dunder1, Margareta H Lejonklou2, P Monica Lind2
1Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden linda.dunder@medsci.uu.se.
Insights
This study found no significant link between bisphenol A (BPA) exposure and lipid levels in children or adults. Further longitudinal research is needed to confirm these findings on endocrine disruptors and metabolic health.
Area of Science:
- Endocrinology
- Environmental Health
- Metabolic Disorders
Background:
- Emerging evidence links bisphenol A (BPA) exposure to metabolic disorders.
- BPA is an endocrine disruptor with potential health implications.
Purpose of the Study:
- To investigate the association between urinary BPA concentrations and dyslipidemia in children and adults.
- Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2003-2014.
Main Methods:
- A meta-analysis of data from 4604 children and 10,989 adults.
- Analysis of six NHANES cycles (2003-2014) using linear regression models.
- Examined associations between urinary BPA and serum lipids: LDL-C, HDL-C, TC, TG, and ApoB.
Main Results:
- No significant associations were found between urinary BPA and lipid profiles in children.
- In adults, while negative regression coefficients were observed for all five lipid variables, none reached statistical significance after Bonferroni correction.
Conclusions:
- This meta-analysis of cross-sectional NHANES data found no association between urinary BPA and key lipid variables in children or adults.
- Longitudinal cohort studies with repeated BPA measurements are recommended to clarify these findings.
Background:
Mounting evidence from both experimental and epidemiological studies suggest that exposure to the endocrine disruptor bisphenol A (BPA) has a role in metabolic disorders. The aim of the present study was to assess whether urinary BPA concentrations were associated with dyslipidaemia in children (≤17 years old) and adults (≥18 years old) by performing a meta-analysis of data from six cycles (2003-2014) in the National Health and Nutrition Examination Survey (NHANES).
Methods:
We conducted a meta-analysis of data from 4604 children and 10 989 adult participants who were part of a substudy of urinary BPA measurements from six NHANES cycles from 2003 to 2014. Linear regression models conducted in each cycle were used to perform a meta-analysis to investigate associations between urinary BPA and serum levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG) and apolipoprotein B (ApoB).
Results:
The meta-analysis did not disclose any significant associations between urinary BPA concentrations and LDL-C, HDL-C, TC, TG and ApoB in children. In adults, the meta-analysis revealed negative regression coefficients for all five lipid variables. However, no associations were significant following Bonferroni correction for multiple tests.
Conclusions:
In the present meta-analysis of cross-sectional data from NHANES, no associations were found between urinary BPA and the five different lipid variables when investigated in both children and adults. However, considering the cross-sectional nature of the present study, results should be clarified in carefully designed longitudinal cohort studies with repeated BPA measurements.
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