Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes
Rahul Upadhyay1,2, Rohit Rana1,2, Aakriti Sood1
1Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology Palampur, Palampur, Himachal Pradesh 176061, India.
Abstract:
A novel formic acid-assisted rapid and efficient route for C-S bond construction via the thiol-ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing different functionalities were well tolerated. The reaction also provided a good yield of sulfones in a one-pot two-step protocol. The developed method is operationally simple, green, metal-free, solvent-free, and having a high atom economy with high regioselectivity.
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