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Updated: Jan 19, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
Published on: February 17, 2017
DNA Copy Number Variations as Markers of Mutagenic Impact
Galina Hovhannisyan1, Tigran Harutyunyan2, Rouben Aroutiounian3
1Department of Genetics and Cytology, Yerevan State University, Alex Manoogian 1, 0025 Yerevan, Armenia. galinahovhannisyan@ysu.am.
Abstract:
DNA copy number variation (CNV) occurs due to deletion or duplication of DNA segments resulting in a different number of copies of a specific DNA-stretch on homologous chromosomes. Implications of CNVs in evolution and development of different diseases have been demonstrated although contribution of environmental factors, such as mutagens, in the origin of CNVs, is poorly understood. In this review, we summarize current knowledge about mutagen-induced CNVs in human, animal and plant cells. Differences in CNV frequencies induced by radiation and chemical mutagens, distribution of CNVs in the genome, as well as adaptive effects in plants, are discussed. Currently available information concerning impact of mutagens in induction of CNVs in germ cells is presented. Moreover, the potential of CNVs as a new endpoint in mutagenicity test-systems is discussed.
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