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Therapeutic management of hyperlipoproteinemia (a)

Constantine E Kosmas1, Andreas Sourlas2, Gordon Mallarkey3

  • 1Department of Medicine, Division of Cardiology, Montefiore Medical Center, Bronx, NY, USA.

Drugs in Context
|September 27, 2019
PubMed

Insights

Elevated lipoprotein (a) [Lp(a)] is a major cardiovascular disease risk. This review discusses current and emerging therapies, including statins and novel treatments like PCSK9 inhibitors, to manage hyperlipoproteinemia (a).

Area of Science:

  • Cardiology
  • Genetics
  • Pharmacology

Background:

  • Cardiovascular disease (CVD) remains the leading global cause of mortality.
  • Elevated plasma lipoprotein (a) [Lp(a)] is a significant, independent risk factor for CVD and calcific aortic valve stenosis.

Purpose of the Study:

  • To review and discuss current and emerging therapeutic strategies for managing hyperlipoproteinemia (a).
  • To assess the potential impact of reducing Lp(a) levels on cardiovascular risk.

Main Methods:

  • Review of current clinical and epidemiological data.
  • Analysis of existing and investigational therapeutic interventions for hyperlipoproteinemia (a).

Main Results:

  • Established therapies like aspirin, niacin, estrogens, and statins may help mild to moderate Lp(a) elevations.
  • Emerging treatments including PCSK9 inhibitors, Lp(a) apheresis, and novel antisense oligonucleotides show promise for severe cases.

Conclusions:

  • Effective management of hyperlipoproteinemia (a) is crucial for reducing cardiovascular risk.
  • A range of therapeutic options exist, from traditional medications to novel agents, offering potential benefits for patients with elevated Lp(a).

Keywords:
cardiovascular diseasecardiovascular riskhyperlipoproteinemia (a)lipoprotein (a)therapeutic management

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