Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.3K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.3K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
963

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Online toxic speech as positioning acts: Hate as discursive mechanisms for othering and belonging.

New media & society·2026
Same author

Prevalence of and risk factors for diabetic retinopathy: The Thessaloniki Eye Study.

Eye (London, England)·2026
Same author

Automated iridocorneal angle classification using a multimodal large language model.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Vision Impairment, Insurance Coverage, and Out-of-Pocket Spending.

JAMA network open·2026
Same author

Definitions of Fast Progression in Glaucoma Literature.

Ophthalmology. Glaucoma·2026
Same author

Impact of visit schedule on estimated success rates in glaucoma surgical studies.

The British journal of ophthalmology·2026

Related Experiment Video

Updated: Jan 19, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K

Comparison of Methods to Detect and Measure Glaucomatous Visual Field Progression.

Alessandro Rabiolo1,2, Esteban Morales1, Lilian Mohamed1,3

  • 1Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Translational Vision Science & Technology
|September 27, 2019
PubMed
Summary

Glaucoma visual field progression detection was compared across multiple methods. Glaucoma Rate Index (GRI) and Permutation of Pointwise Linear Regression (PoPLR) demonstrated the fastest and most frequent detection of visual field progression.

Keywords:
Advanced Glaucoma Intervention StudyCollaborative Initial Glaucoma Treatment Studyglaucoma rate indexguided progression analysismean deviationperimetrypermutation of pointwise linear regressionvisual field ratevisual field simulation

More Related Videos

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
07:45

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

4.9K
Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.2K

Related Experiment Videos

Last Updated: Jan 19, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K
Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
07:45

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

4.9K
Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.2K

Area of Science:

  • Ophthalmology
  • Medical Technology
  • Data Science

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Accurate assessment of visual field (VF) progression is crucial for managing glaucoma and preventing vision loss.
  • Various statistical methods exist to analyze VF data, but their comparative performance in detecting progression is not fully established.

Purpose of the Study:

  • To systematically compare the efficacy of different methods for detecting visual field progression in patients with primary open-angle glaucoma.
  • To evaluate the performance of established and novel progression detection algorithms using a large dataset of longitudinal visual fields.

Main Methods:

  • Analysis of 4,950 visual fields from 253 primary open-angle glaucoma patients.
  • Comparison of progression detection using clinical evaluation, Guided Progression Analysis (GPA), Mean Deviation (MD) rate, Visual Field Index (VFI) rate, Advanced Glaucoma Intervention Study (AGIS) and Collaborative Initial Glaucoma Treatment Study (CIGTS) scores, Pointwise Linear Regression (PLR), Permutation of PLR (PoPLR), and Glaucoma Rate Index (GRI).
  • Assessment of a simulated series of longitudinal VFs using all methods except GPA and clinical evaluation to determine discriminative ability.

Main Results:

  • Glaucoma Rate Index (GRI) and Permutation of PLR (PoPLR) identified the highest proportion of progressing cases (58% and 65%, respectively) with the shortest median detection times (7.5 and 7.3 years).
  • Conventional methods like MD and VFI rates showed lower detection rates and significantly longer times to progression detection.
  • In simulated data, GRI demonstrated the best performance in distinguishing glaucoma progression from aging or cataract effects.

Conclusions:

  • GRI and PoPLR emerge as highly effective methods for detecting visual field progression in glaucoma, offering faster and more sensitive identification of disease advancement.
  • The findings underscore the importance of selecting appropriate analytical tools for glaucoma progression monitoring.
  • Understanding the performance characteristics of each method enables tailored application in both clinical practice and research settings for optimized patient management.