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Updated: Jan 19, 2026

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging
Published on: November 10, 2015
[Normal and pathological hippocampal imaging in geriatric patients]
Damien Combes1, Jean-Yves Tanguy1, Cédric Annweiler2
1Département de radiologie, CHU d'Angers, France.
Abstract:
The hippocampus is a small internal temporal cerebral structure, which plays a primordial role in the mechanisms of memory. Magnetic resonance imaging (MRI) is the reference imaging modality for the hippocampal analysis. In older adults, dementia represents the majority of hippocampal diseases, but other specific pathologies must be known in the differential diagnosis. Many hippocampal abnormalities are represented by a loss of substance (atrophy). However, most acute or recent hippocampal damage is detected by MRI signal abnormalities. The aim of this article is to offer a pictorial review of the normal and pathological hippocampal aspects of older adults, during degenerative, infectious, vascular, inflammatory, tumoral, toxic and metabolic disorders.
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