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Inducible rodent models of glaucoma
1North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, USA; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Progress in Retinal and Eye Research
|September 27, 2019
Summary
Rodent models, including rats and mice, are crucial for understanding glaucoma, a leading cause of vision loss. These models help researchers develop new therapies by mimicking human eye conditions and allowing for genetic manipulation.
Area of Science:
- Ophthalmology
- Animal Models
- Molecular Pathobiology
Background:
- Glaucoma is a primary cause of global vision impairment.
- Understanding glaucoma's molecular pathobiology requires clinically relevant animal models.
- Rats and mice are increasingly utilized in glaucoma research due to biological similarities and available genetic tools.
Purpose of the Study:
- To review commonly studied rat and mouse glaucoma models.
- To describe the characterization, induction techniques, and injury mechanisms of these models.
- To outline the advantages and limitations of pressure-dependent and pressure-independent glaucoma models.
Main Methods:
- Review of existing literature on rodent glaucoma models.
- Description of techniques for inducing intraocular pressure (IOP)-dependent glaucoma.
- Explanation of methods for studying pressure-independent glaucoma models.
Main Results:
- Identified key similarities between rodent and human eyes making them suitable models.
- Detailed pressure-dependent models targeting elevated IOP and pressure-independent models for normal-tension glaucoma.
- Highlighted the availability of genetic tools in mice and cost-effectiveness of rodent studies.
Conclusions:
- Rat and mouse models offer valuable insights into glaucoma's mechanisms.
- These models facilitate the development of novel therapeutic strategies for vision impairment.
- Both IOP-dependent and independent models are essential for comprehensive glaucoma research.
