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Choroidal Nevus with Retinal Invasion in 8 Cases
Stephanie J Weiss1,2, Christina Stathopoulos1,3, Carol L Shields1
1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Ocular Oncology and Pathology
|September 28, 2019
Summary
Choroidal nevus with retinal invasion is rare, with only one case transforming to melanoma in a series of eight. Long-term monitoring is recommended for these rare ocular tumors.
Area of Science:
- Ophthalmology
- Oncology
- Medical Imaging
Background:
- Choroidal nevi can induce chronic retinal pigment epithelium (RPE) changes.
- Frank retinal invasion by choroidal nevus is exceptionally uncommon.
Purpose of the Study:
- To review clinical and imaging features of choroidal nevus with retinal invasion.
- To assess the progression and malignant transformation potential of these rare lesions.
Main Methods:
- Retrospective review of 8 cases of choroidal nevus with retinal invasion.
- Evaluation of clinical presentation, B-scan ultrasonography, and optical coherence tomography (OCT) findings.
- Analysis of long-term follow-up data, including tumor growth and management.
Main Results:
- Mean age at diagnosis was 65 years; mean tumor diameter 7 mm, thickness 2.3 mm.
- Retinal invasion was visible ophthalmoscopically and confirmed by OCT (outer and inner retina).
- Hypoautofluorescence correlated with nevus stability (p=0.035); one case transformed to melanoma over 40 months.
Conclusions:
- Retinal invasion of choroidal nevus is a rare entity.
- Long-term surveillance is crucial for detecting potential malignant transformation.
- Hypoautofluorescence may indicate nevus stability.
