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Drugs for Treatment of Constipation-Predominant IBS01:21

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Lewy body constipation.

Ryuji Sakakibara1, Hirokazu Doi2, Shin Fukudo3

  • 1Neurology, Internal Medicine, Sakura Medical Center, Toho University, Shimoshizu, Japan.

Journal of the Anus, Rectum and Colon
|September 28, 2019
PubMed
Summary

Constipation may be an early sign of Lewy body diseases (LBD), often preceding neurological symptoms. Early detection and management of Lewy body constipation are crucial for improving patient quality of life.

Keywords:
Lewy body constipationParkinson's diseaseconstipationdementia with Lewy bodiesneuroimaging

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Area of Science:

  • Geriatric Medicine
  • Neurology
  • Gastroenterology

Background:

  • Constipation is a common geriatric issue.
  • Lewy body diseases (LBD) are a spectrum of neurodegenerative disorders.
  • Constipation can be an early, isolated symptom of LBD.

Purpose of the Study:

  • To systematically review literature on constipation as an early manifestation of Lewy body diseases (LBD).
  • To explore the epidemiology, pathology, and diagnostic methods for Lewy body constipation.
  • To highlight the importance of interdisciplinary collaboration in managing this condition.

Main Methods:

  • Systematic literature review of studies on "Lewy body constipation" and LBD.
  • Analysis of epidemiological and pathological data.
  • Evaluation of neuroimaging techniques (MIBG scintigraphy, DAT scan) and clinical features.

Main Results:

  • Lewy body diseases can manifest initially as isolated constipation, linked to neuronal loss in the myenteric plexus.
  • The incidence of Lewy body constipation is expected to rise with an aging population.
  • Neuroimaging and specific non-motor symptoms like REM sleep behavior disorder aid in diagnosis.

Conclusions:

  • Lewy body constipation may represent a distinct geriatric constipation category requiring specialized follow-up.
  • Early identification and management, potentially involving add-on therapies, are vital.
  • Collaboration between gastroenterologists and neurologists is essential for optimal patient care and quality of life.