A self-assembly of an active tumor-targeted photothermal agent for enhanced anti-inflammatory cancer therapy
Hongyu Wang1, Jinjie Chang, Wei Pan
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P.R. China. lina@sdnu.edu.cn tangb@sdnu.edu.cn.
Abstract:
A self-assembly of an active tumor-cell-targeted photothermal agent, functionalized with a cyclic Arg-Gly-Asp peptide and ibuprofen, for killing cancer cells and eliciting anti-inflammatory responses was developed. In vitro and in vivo experiments also demonstrated that the photothermal material exhibited low cytotoxicity, good biological compatibility and excellent tumor inhibitory effects.
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