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Updated: Jan 19, 2026
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
Optical Coherence Tomography Angiography Findings in Active and Inactive Ocular Behçet Disease
Massimo Accorinti1, Marta Gilardi2, Daniele De Geronimo2
1Department of Ophthalmology, Sapienza University of Rome , Rome, Italy.
Purpose:
To study macular microvascular changes in ocular Behçet disease (OBD) using optical coherence tomography angiography (OCTA).
Methods:
Quantitative and qualitative analyses of OCTA were performed on 23 OBD patients with active or inactive uveitis and compared with healthy controls.
Results:
Deep capillary plexus (DCP) is the most frequently involved in OBD (p < 0.001). Its vessel density (VD) is reduced compared with controls in both active (p < 0.007) and inactive uveitis (p = 0.03). In inactive uveitis, VD is inversely related to the number of uveitis relapses (superficial capillary plexus: r = -0.694, p = 0.004; DCP: r = -0.541, p = 0.037) and it is significantly reduced in patients with a uveitis-free period ≥5 years compared with healthy controls (p < 0.038).
Conclusions:
Macular VD is reduced in Behçet patients with active and inactive uveitis, especially in DCP. In inactive uveitis, VD is inversely related to the number of ocular relapses and cannot be restored during time.
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