THE STUDY OF SKIN AUTOFLORA'S PATHOGENIC PROPERTIES IN PATIENTS DIAGNOSED WITH ATOPIC DERMATITIS

Area of Science:

• Microbiology
• Immunology
• Dermatology

Background:

• Atopic dermatitis (AD) development is linked to skin microflora and immune disorders.
• Staphylococcus aureus is found in 80-95% of AD patients, playing a key role.
• Pathogen survival in the skin biotope is facilitated by virulence factors.

Purpose of the Study:

• To investigate the activity of virulence factors in Staphylococcus aureus strains.
• To assess the persistence of clinical Staphylococcus aureus strains from AD patients.
• To compare strains from affected and unaffected skin areas in AD patients.

Main Methods:

• Classical bacteriology techniques were used for isolation and study.
• 101 Staphylococcus aureus strains from 50 AD patients were analyzed.
• 39 control strains from 20 healthy individuals were used for comparison.

Main Results:

• Strains from affected skin areas exhibited significantly higher antilysocyme activity (ALA).
• Strains from affected skin areas showed significantly higher anti-interferon activity (AIA).
• Adhesive properties were also significantly elevated in strains from lesional skin.

Conclusions:

• Increased virulence factors in Staphylococcus aureus strains from AD lesions suggest a role in disease exacerbation.
• These findings highlight the contribution of specific microbial factors to the pathogenesis of atopic dermatitis.
• Targeting these virulence factors could be a potential therapeutic strategy for AD.