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Published on: April 23, 2012
Characterization of Eight Novel Spiroleptosphols from Fusarium avenaceum
Klaus Ringsborg Westphal1, Manuela Ilse Helga Werner2, Katrine Amalie Hamborg Nielsen3
1Department of Chemistry and Bioscience-Section for Biotechnology, Aalborg University, Frederik Bajers Vej 7H, 9220 Aalborg Ø, Denmark. kw@bio.aau.dk.
Abstract:
Chemical analyses of Fusarium avenaceum grown on banana medium resulted in eight novel spiroleptosphols, T1, T2 and U-Z (1-8). The structures were elucidated by a combination of high-resolution mass spectrometric data and 1- and 2-D NMR experiments. The relative stereochemistry was assigned by 1H coupling and NOESY/ROESY experiments. Absolute stereochemistry established for 7 by vibrational circular dichroism was found analogous to that of the putative polyketide spiroleptosphol from Leptosphaeria doliolum.
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