Related Experiment Video
Updated: Jan 18, 2026

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
Published on: September 6, 2024
A Bifactor Model of the Autism Spectrum Disorder Phenotype
1Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN.
Abstract:
I read with interest the newly published work by Kim et al. describing the covariance structure of parent-reported autism spectrum disorder (ASD) symptoms.1 The authors compared many different latent class, factor analytic, and factor mixture models in a large, clinically referred sample, concluding that the ASD phenotype is best described by three continuous latent factors of social interaction, communication, and repetitive behavior. I found the study to be methodologically rigorous, employing robust estimation techniques, testing a wide range of categorical-dimensional hybrid models, and even replicating the rank-order of model choices in a separate sample. However, given the large reported interfactor correlations in the final model (r = 0.78-0.83; Kim et al., Figure 2), I was disappointed that the authors did not explore a bifactor model2 of ASD phenotypic traits. In this correspondance, I aim to demonstrate the ways in which bifactor models provide further insight into the structures of complex psychopathological constructs.
Related Concept Videos
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Pedigree Analysis
Probability Laws
Factorial Design
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...

