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Updated: Jan 18, 2026
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
Clinical relevance of semaphorin-3F in patients with prostate cancer
1Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin- Buch, Germany; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Buch, Germany. guanlin.wu@charite.de.
Purpose:
To identify prognosis predictors for patients with prostate cancer (PCa).
Methods:
Four independent PCa microarray datasets (GSE32448, GSE16560, GSE79957 and GSE17951) were reanalyzed to characterize the expression of semaphorin-3F (SEMA3F) gene between PCa patients and normal prostate tissues and the correlation between SEMA3F expression and the age, tumor/nodes/metastasis (TNM) staging, Gleason Grade Group, prostate-specific antigen level and overall survival of PCa patients. Gene set enrichment analysis was applied to investigate the potential relevant mechanisms regarding the expression of SEMA3F and the proliferation of PCa cells.
Results:
The level of SEMA3F was significantly higher in normal prostate tissues compared with that in PCa cells (P.
