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Updated: Jan 18, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Migraine: Epidemiology, Burden, and Comorbidity
Rebecca C Burch1, Dawn C Buse2, Richard B Lipton3
1Department of Neurology, John R. Graham Headache Center, Brigham and Women's Hospital, Harvard Medical School, 1153 Centre Street, Suite 4H, Jamaica Plain, MA 02130, USA.
Migraine impacts many globally, with chronic migraine (CM) affecting 1-2%. Understanding CM progression and its associated risks is crucial for managing this disabling condition.
Area of Science:
- Neurology
- Epidemiology
Background:
- Migraine affects approximately 12% of the population globally.
- Chronic migraine (CM) impacts 1% to 2% of the global population, with 2.5% of episodic migraine cases progressing to CM.
- Migraine is a leading cause of disability worldwide, second only to lower back pain.
Purpose of the Study:
- To explore the progression of episodic migraine to chronic migraine (CM).
- To identify risk factors associated with the transition to CM.
- To understand the broader impact of CM on patients' lives and healthcare systems.
Main Methods:
- This study synthesizes existing epidemiological data on migraine prevalence and progression.
- It reviews literature identifying risk factors for chronic migraine development.
- Analysis includes the association of migraine with other health conditions and socioeconomic factors.
Main Results:
- Significant short-term variability in migraine frequency exists, independent of treatment.
- Migraine is linked to increased risks of cardiovascular disease, psychiatric disorders, and sleep disturbances.
- Chronic migraine is associated with greater disability, comorbidities, healthcare utilization, and reduced quality of life.
Conclusions:
- Migraine, particularly chronic migraine, represents a significant global health burden.
- Identifying progression factors and associated conditions is key to improving patient outcomes.
- CM negatively impacts multiple facets of a patient's life, including socioeconomic status and quality of life.
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