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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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An Update: Pathophysiology of Migraine
Peter J Goadsby1, Philip R Holland1
1Headache Group, Basic and Clinical Neurosciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
Neurologic Clinics
|September 30, 2019
Summary
Migraine, a common disabling headache, involves abnormal brain responses to internal and external cues. These dysfunctional homeostatic mechanisms increase susceptibility to debilitating migraine attacks.
Area of Science:
- Neurology
- Neuroscience
- Headache Medicine
Background:
- Migraine is a prevalent, disabling primary headache disorder worldwide.
- Attacks are characterized by unilateral throbbing pain, nausea, fatigue, and sensory hypersensitivity.
Purpose of the Study:
- To explore the neuroanatomical underpinnings of migraine-related headaches.
- To discuss clinical and preclinical evidence suggesting migraine arises from disrupted homeostatic mechanisms.
Main Methods:
- Review of neuroanatomical basis for migraine headache.
- Analysis of clinical and preclinical findings related to migraine pathophysiology.
Main Results:
- Migraine pathophysiology involves dysfunctional central nervous system (CNS) homeostatic mechanisms.
- Abnormal CNS responses to various cues heighten susceptibility to migraine attacks.
Conclusions:
- Migraine susceptibility is linked to impaired homeostatic regulation within the CNS.
- Understanding these mechanisms is crucial for developing effective migraine treatments.
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