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Updated: Jan 18, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Spectrofluorimetric method for determination of bupropion in pharmaceutical dosage forms
E Souri1, S Rahmatpoor1, M Barazandeh Tehrani1
1Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.
Objective:
Bupropion is a noradrenaline and dopamine reuptake inhibitor which is used as an antidepressant drug. Few HPLC and spectrophotometric methods have been reported before for the determination of bupropion. Most of the previous methods reported for determination of bupropion in pharmaceutical dosage forms are somehow dangerous to health and environment because of using organic solvents.
Method:
In the present method bupropion was determined in pharmaceutical dosage forms by spectrofluorimetry after ion-pair complex formation with eosin Y. The ion-pair complex formation was optimized for reagent amount, buffer pH and time.
Result:
The developed method was linear over the range of 3-120μgmL-1 with an acceptable precision (CV<1.5%) and accuracy (Error<1%).
Conclusion:
The present method is applicable for determination of bupropion in pharmaceutical dosage forms for routine quality control analysis.
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