Pharmaceutical applications of electrospinning

Development of tailor-made pharmaceutical nanofibers has gained vital prominence due to ease of fabrication and versatility of electrospinning (ES). ES is one of the flexible and, wonderful strategies for the fabrication of nanofibers. ES unit comprises a supplier of high voltage current, a syringe (pump), spinneret and a metal plate collector. The obtained nanofibers are optimized by manipulating process and formulation variables Viz: polymer/drug resolution (viscosity, concentration, physical phenomenon, molecular mass) and the environmental conditions (humidity, temperature). The electrospun nanofibers can be used for loading of the drug, amorphization of a crystalline API and an increase in its physical storage stability. ES technique enables mixing of two or more API and may facilitate or inhibit the burst release of a drug, along with attainment of modified release. Additionally, nanofibers demonstrate a reduction in overall dose needed for the therapeutic activity, by improving dissolution and bioavailability of the drugs. The current review is an attempt to focus on ES method, the optimization parameters, and pharmaceutical applications of the electrospun nanofibers.