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Updated: Jan 18, 2026

Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology
Published on: March 22, 2024
Evaluation of hyperspectral NIRS for quantitative measurements of tissue oxygen saturation by comparison to
Matthew Kewin1,2, Ajay Rajaram1,2, Daniel Milej1,2
1Imaging Program, Lawson Health Research Institute, London, Ontario, N6A 4V2, Canada.
Abstract:
Near-infrared spectroscopy (NIRS) is considered ideal for brain monitoring during preterm infancy because it is non-invasive and provides a continuous measure of tissue oxygen saturation (StO2). Hyperspectral NIRS (HS NIRS) is an inexpensive, quantitative modality that can measure tissue optical properties and oxygen saturation (StO2) by differential spectroscopy. In this study, experiments were conducted using newborn piglets to measure StO2 across a range of oxygenation levels from hyperoxia to hypoxia by HS and time-resolved (TR) NIRS for validation. A strong correlation between StO2 measurements from the two techniques was observed (R2 = 0.98, average slope of 1.02 ± 0.28); however, the HS-NIRS estimates were significantly higher than the corresponding TR-NIRS values. These regression results indicate that HS NIRS could become a clinically feasible method for monitoring StO2 in preterm infants.
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