OGRDB: a reference database of inferred immune receptor genes

Area of Science:

• Immunology
• Bioinformatics
• Genomics

Background:

• Adaptive immune receptor sequencing (AIRR-seq) offers deep insights into immune responses and disorders.
• Accurate AIRR-seq data interpretation requires comprehensive germline gene reference sets.
• Existing reference sets are limited, lacking representation of population polymorphism and diversity.

Purpose of the Study:

• To address the limitations of current germline gene reference sets.
• To introduce a public resource for novel germline receptor sequences.
• To facilitate community-driven curation and publication of inferred sequences.

Main Methods:

• Leveraging tools and methods for inferring germline gene sequences from AIRR-seq data.
• Implementing a community approach for expert review and publication of inferred sequences.
• Establishing the Open Germline Receptor Database (OGRDB) as a public repository.

Main Results:

• OGRDB provides a centralized platform for novel germline receptor sequence submission.
• The database supports expert review and publication of inferred sequences.
• It aims to expand the known diversity of germline receptor genes.

Conclusions:

• OGRDB enhances the accuracy and comprehensiveness of germline gene reference sets.
• This resource will improve the interpretation of AIRR-seq data.
• It fosters collaborative efforts in cataloging immune receptor diversity.