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Overcoming trastuzumab resistance in HER2-positive breast cancer using combination therapy

Afshin Derakhshani1, Zohreh Rezaei2, Hossein Safarpour3

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Cellular Physiology
|October 1, 2019
PubMed

Insights

Trastuzumab resistance in HER2-positive breast cancer (BC) is a challenge. This review explores resistance mechanisms and new therapies for improved HER2-positive BC treatment.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • HER2-positive breast cancer (BC) accounts for 20-30% of BC cases and is linked to poor prognosis.
  • Trastuzumab, a monoclonal antibody, has been a standard treatment for inhibiting HER2 activity.
  • Resistance to trastuzumab poses a significant clinical challenge in managing HER2-positive BC.

Purpose of the Study:

  • To review the mechanisms underlying trastuzumab resistance in HER2-positive BC.
  • To identify and discuss innovative therapeutic agents investigated for trastuzumab-resistant HER2-positive BC.

Main Methods:

  • Literature review of studies on trastuzumab resistance mechanisms.
  • Analysis of recent therapeutic developments for trastuzumab-resistant HER2-positive BC.

Main Results:

  • Identified key mechanisms contributing to trastuzumab resistance.
  • Highlighted novel therapeutic strategies showing promise in preclinical and clinical settings.

Conclusions:

  • Understanding trastuzumab resistance is crucial for developing effective treatment strategies.
  • Emerging therapies offer potential for improved outcomes in patients with trastuzumab-resistant HER2-positive BC.
Keywords:
HER2 positivebreast cancerdrug resistancetrastuzumab

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