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Related Concept Videos

Obesity01:24

Obesity

1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

226
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
226
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

228
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
228
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

234
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
234
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

248
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
248
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

190
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
190

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Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
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Overweight: A Protective Factor against Comorbidity in the Elderly.

Giovanni Mario Pes1,2, Giulia Licheri3, Sara Soro4

  • 1Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, University of Sassari, 07100 Sassari, Italy. gmpes@uniss.it.

International Journal of Environmental Research and Public Health
|October 2, 2019
PubMed
Summary

Moderate overweight may indicate healthy aging. This study found that a body mass index (BMI) between 27.5–29.9 kg/m² was associated with lower comorbidity risk in older adults, suggesting a protective effect against illness.

Keywords:
Body heightSardiniacomorbidity

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Area of Science:

  • Gerontology
  • Public Health
  • Epidemiology

Background:

  • Body Mass Index (BMI) is a common metric for assessing weight status.
  • Comorbidity, the presence of one or more additional conditions co-occurring with a primary condition, is a significant concern in aging populations.
  • Understanding the relationship between BMI and comorbidity is crucial for public health initiatives and clinical practice.

Purpose of the Study:

  • To investigate the association between different Body Mass Index (BMI) categories and the prevalence of comorbidity.
  • To explore how this relationship varies across different age groups.
  • To determine if moderate overweight is associated with a healthier aging process and reduced comorbidity.

Main Methods:

  • A cross-sectional study involving 9067 patients undergoing upper digestive endoscopy in Northern Sardinia, Italy.
  • Data collected included patient demographics, BMI, and recorded illnesses such as hypertension, cardiovascular, and liver disease.
  • Multivariate analysis adjusted for factors including age, sex, residence, marital status, smoking habits, occupation, and hospitalization.

Main Results:

  • The majority of participants (62.2%) had a BMI under 25 kg/m², with 30.4% classified as overweight and 7.4% as obese.
  • A significant, progressive association between comorbidity and aging was detected.
  • In patients younger than 60, higher comorbidity risk was observed for BMI 27.5–29.9 kg/m² compared to BMI 25.0–27.4 kg/m². Conversely, in patients older than 60, the risk was lower for BMI 27.5–29.9 kg/m² compared to BMI 25.0–27.4 kg/m².

Conclusions:

  • Moderate overweight (BMI 27.5–29.9 kg/m²) appears to be a marker of healthy aging in individuals over 60.
  • This BMI range may offer partial protection against comorbidity in older adults.
  • Further research is warranted to elucidate the mechanisms behind this unexpected finding and its clinical implications.