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Artificial Intelligence as a Safeguard for Clinical Scientific Integrity: A Human-AI Hybrid Model for Medical Peer
Maria Pina Dore1,2, Elettra Merola1, Giuseppe Lasaracina1
1Dipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy.
Journal of Clinical Medicine
|March 28, 2026
Summary
Artificial intelligence (AI) and large language models (LLMs) can enhance medical peer review by detecting errors and bias. A hybrid approach, combining AI screening with human expertise, promises more reliable clinical evidence.
Area of Science:
- Medical publishing
- Scholarly communication
- Clinical evidence integrity
Background:
- Current medical peer review faces challenges like bias, reviewer overload, and potential misconduct.
- These issues compromise the trustworthiness of scientific literature used for clinical decisions.
- Existing peer review systems struggle to maintain high standards of reliability and fairness.
Purpose of the Study:
- To explore the potential of artificial intelligence (AI) and large language models (LLMs) in improving medical peer review.
- To address the limitations and risks associated with AI in scholarly publishing.
- To propose a hybrid human-AI model for enhanced peer review processes.
Main Methods:
- Review of current challenges in medical peer review.
- Analysis of AI and LLM capabilities for manuscript evaluation (e.g., consistency checks, plagiarism detection, compliance monitoring).
- Discussion of AI limitations (hallucinations, lack of judgment, confidentiality risks).
Main Results:
- AI tools can expedite manuscript screening, identify statistical errors, detect plagiarism, and enforce standards.
- Early AI implementations show potential for more thorough, objective, and reproducible reviews.
- AI offers a scalable solution to manage the increasing volume of submissions.
Conclusions:
- AI and LLMs present a significant opportunity to bolster the integrity and efficiency of medical peer review.
- A hybrid model, leveraging AI for routine tasks and human experts for final evaluation, is proposed.
- This human-AI collaboration is crucial for enhancing the quality, fairness, and reliability of the clinical evidence base.
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