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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
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Tissue Engineering and Stem Cell Therapy in Pediatric Urology.

Shilpa Sharma1, Devendra K Gupta1

  • 1Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Journal of Indian Association of Pediatric Surgeons
|October 2, 2019
PubMed
Summary

Tissue engineering and stem cell therapy show promise for pediatric urology, with functional biounits for renal regeneration and bladder tissue repair. Advances include 3D organoids and stem cell-derived treatments for urinary incontinence.

Keywords:
Bone marrow cellscell therapynanotechnology

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Area of Science:

  • Regenerative Medicine
  • Pediatric Urology
  • Stem Cell Therapy

Background:

  • Tissue engineering and stem cell therapy offer innovative solutions for pediatric urological conditions.
  • Significant progress has been made in renal regeneration and bladder tissue engineering.

Purpose of the Study:

  • To review experimental and clinical advancements in tissue engineering and stem cell therapy for pediatric urological applications.
  • To highlight the potential of these technologies in addressing unmet clinical needs.

Main Methods:

  • Review of current literature on stem cell-derived organoids, tissue regeneration techniques, and cell-based therapies.
  • Analysis of preclinical and clinical studies in pediatric urology.

Main Results:

  • Successful development of functional biounits for renal regeneration and urine excretion from stem cell-generated kidneys.
  • Clinical application of myoblast and fibroblast therapy for urinary incontinence, including stress urinary incontinence.
  • Emerging 3D bioprinting techniques for urethral regeneration and advancements in artificial germ cell production.

Conclusions:

  • Tissue engineering and stem cell therapy represent a paradigm shift in pediatric urology, offering novel therapeutic strategies.
  • Continued research and clinical translation hold significant promise for improving patient outcomes.