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Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Related Experiment Video

Updated: Jan 6, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
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Quorum Sensing by Monocyte-Derived Populations.

Jérémy Postat1,2, Philippe Bousso1

  • 1Dynamics of Immune Responses Unit, Institut Pasteur, INSERM U1223, Paris, France.

Frontiers in Immunology
|October 2, 2019
PubMed
Summary
This summary is machine-generated.

Quorum sensing, a bacterial communication method, may also occur in immune cells. This cell-density-dependent signaling influences immune responses and cell behavior, impacting health and disease.

Keywords:
macrophagemetabolismmonocytemonocyte-derived cellnitric oxidequorum sensing (QS)

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Area of Science:

  • Immunology
  • Microbiology
  • Cellular Communication

Background:

  • Quorum sensing (QS) is a cell-to-cell communication mechanism in bacteria, regulating gene expression based on population density.
  • Bacteria use autoinducers to sense their environment and coordinate group behaviors like biofilm formation and virulence.
  • Emerging evidence suggests QS mechanisms extend beyond bacteria to eukaryotic cells, including immune cells.

Purpose of the Study:

  • To review the prototypic features of bacterial quorum sensing.
  • To discuss the evidence for quorum sensing in the immune system, particularly in monocyte-derived cells.
  • To explore the implications of immune cell quorum sensing in homeostasis and disease.

Main Methods:

  • Literature review of quorum sensing mechanisms in bacteria.
  • Analysis of existing research on immune cell communication and density-dependent regulation.
  • Focus on monocyte-derived cells and their role in inflammation and nitric oxide production.

Main Results:

  • Quorum sensing principles observed in bacteria are potentially applicable to immune cell interactions.
  • Monocyte-derived cells exhibit density-dependent regulation of functions like nitric oxide production, suggesting immune QS.
  • Immune cell QS could influence population dynamics and coordinated responses during homeostasis and immune reactions.

Conclusions:

  • Quorum sensing represents a novel paradigm for understanding immune cell communication.
  • Immune cell QS mechanisms, though not fully elucidated, challenge traditional views of immune interactions.
  • Further research into immune autoinducers and QS pathways is crucial for understanding immune-related pathologies.