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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

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Nanoparticles in the clinic: An update.

Aaron C Anselmo¹, Samir Mitragotri²

¹Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina.

Bioengineering & Translational Medicine

|October 2, 2019

Summary

Nanoparticle drug delivery systems have advanced significantly, with new generations enabling novel therapies. This review updates the clinical landscape, highlighting approved nanomedicines and emerging technologies.

Keywords:

clinic clinical translation clinical trials drug delivery nanomedicine nanoparticles translational medicine

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Area of Science:

Biomedical Engineering
Nanotechnology
Translational Medicine

Background:

Nanoparticle drug delivery systems have been clinically utilized since the early 1990s.
The field of nanomedicine has evolved with technological advancements to enhance therapeutic delivery.
Newer nanoparticle generations offer advanced functionalities for novel therapeutic modalities.

Purpose of the Study:

To provide a three-year update on the clinical landscape of nanoparticle drug delivery systems.
To highlight newly approved nanomedicines and their indications.
To review the status of ongoing clinical trials and new technologies entering the clinic.

Main Methods:

Literature review and analysis of clinical trial data.
Identification and summary of recently approved nanomedicines.
Assessment of technological advancements in nanoparticle drug delivery.

Main Results:

Several new-generation nanoparticles have reached clinical trials and gained approval for various indications.
Updates on the progress of previously reviewed clinical trials are provided.
Emerging technologies in nanoparticle-based drug delivery have been identified.

Conclusions:

The field of nanomedicine continues to rapidly advance, with increasing clinical translation of nanoparticle drug delivery systems.
Ongoing research and development are expanding the therapeutic potential of nanomedicines.
The clinical application of nanotechnology in drug delivery is a dynamic and growing area.